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ORIGINAL ARTICLE: Sirolimus for Angiomyolipoma in Tuberous Sclerosis Complex or Lymphangioleiomyomatosis

Background Angiomyolipomas in patients with the tuberous sclerosis complex or sporadic lymphangioleiomyomatosis are associated with mutations in tuberous sclerosis genes resulting in constitutive activation of the mammalian target of rapamycin (mTOR). ...

From BISSLER, J. J., MCCORMACK, F. X., YOUNG, L. R., ELWING, J. M., CHUCK, G., LEONARD, J. M., SCHMITHORST, V. J., LAOR, T., BRODY, A. S., BEAN, J., SALISBURY, S., FRANZ, D. N., New England Journal of Medicine -- Recent Issues,  9 Jan 2008

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